DNA Binding Motif

Accessions: 5z6z_A (3D-footprint 20231221)
Names: Double homeobox protein 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of human DUX4 homeodomains bound to DNA
Length: 12
Consensus: TGATtAgATTAG
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 0 0 96 0 G
03 96 0 0 0 A
04 2 9 4 81 T
05 16 9 14 57 t
06 76 7 9 4 A
07 11 14 57 14 g
08 96 0 0 0 A
09 0 0 0 96 T
10 0 0 0 96 T
11 96 0 0 0 A
12 0 4 86 6 G
Binding TFs: 5z6z_A (Homeobox domain, Homeobox KN domain)
Binding Sites: 5z6z_D
5z6z_E
Publications: Li Y, Wu B, Liu H, Gao Y, Yang C, Chen X, Zhang J, Chen Y, Gu Y, Li J, Ma J, Gan J. Structural basis for multiple gene regulation by human DUX4. Biochem Biophys Res Commun 505:1161-1167 (2018). [Pubmed]

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