DNA Binding Motif

Accessions: MA0631.1 (JASPAR 2024), PH0163.1 (JASPAR 2024)
Names: Six3
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: universal protein binding microarray (PBM)
Length: 17
Consensus: rAtrGGGTATCAywwwt
Weblogo:
PSSM: P0 A C G T
01 33 9 36 21 r
02 72 8 8 12 A
03 23 5 17 55 t
04 47 10 32 10 r
05 7 7 82 4 G
06 2 2 90 7 G
07 16 1 83 0 G
08 0 0 4 95 T
09 97 0 3 0 A
10 0 0 0 99 T
11 1 97 0 1 C
12 92 3 3 2 A
13 19 45 9 27 y
14 25 23 20 32 w
15 40 8 11 40 w
16 34 22 18 27 w
17 8 11 24 58 t
Type: Heterodimer
Binding TFs: Q62233 (Homeobox domain, Homeobox KN domain)
Q62233
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]

Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

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