DNA Binding Motif

Accessions: 4kfc_AB (3D-footprint 20231221)
Names: KDP operon transcriptional regulatory protein KdpE
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a hyperactive mutant of response regulator KdpE complexed to its promoter DNA
Length: 18
Consensus: TGTAAaannnnTnnaAAA
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 4 1 90 1 G
03 4 1 1 90 T
04 96 0 0 0 A
05 90 3 3 0 A
06 58 5 20 13 a
07 64 5 14 13 a
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 0 0 0 96 T
13 24 24 24 24 n
14 24 24 24 24 n
15 64 8 11 13 a
16 96 0 0 0 A
17 90 3 2 1 A
18 82 13 0 1 A
Type: Heterodimer
Binding TFs: 4kfc_A (Response regulator receiver domain, Transcriptional regulatory protein, C terminal)
4kfc_B (Response regulator receiver domain, Transcriptional regulatory protein, C terminal)
Binding Sites: 4kfc_Y
4kfc_Z
Publications: Narayanan A, Kumar S, Evrard A.N, Paul L.N, Yernool D.A. An asymmetric heterodomain interface stabilizes a response regulator-DNA complex. Nature communications 5:3282 (2014). [Pubmed]

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