DNA Binding Motif

Accessions: 4l0z_AB (3D-footprint 20231221)
Names: Runt-related transcription factor 1
Organisms: Mus musculus, Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 2)
Length: 12
Consensus: AAgCCACATCCT
Weblogo:
PSSM: P0 A C G T
01 84 0 7 5 A
02 73 11 0 12 A
03 16 5 64 11 g
04 0 96 0 0 C
05 0 96 0 0 C
06 96 0 0 0 A
07 0 96 0 0 C
08 75 5 11 5 A
09 0 0 0 96 T
10 0 96 0 0 C
11 0 96 0 0 C
12 5 5 5 81 T
Type: Heterodimer
Binding TFs: 4l0z_A (Runt domain)
4l0z_B (Ets-domain)
Binding Sites: 4l0z_C
4l0z_D
Publications: Shrivastava T, Mino K, Babayeva N.D, Baranovskaya O.I, Rizzino A, Tahirov T.H. Structural basis of Ets1 activation by Runx1. Leukemia 28:2040-8 (2014). [Pubmed]

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