DNA Binding Motif

Accessions: 1io4_ABC (3D-footprint 20231221)
Names: CAAT/ENHANCER BINDING PROTEIN BETA
Organisms: Homo sapiens, Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN-CBFBETA CORE DOMAIN HETERODIMER AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER
Length: 17
Consensus: TTTCCAAAnnnTGTGGT
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 5 15 6 70 T
03 0 0 0 96 T
04 0 96 0 0 C
05 11 75 5 5 C
06 80 5 5 6 A
07 96 0 0 0 A
08 86 5 5 0 A
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 1 5 5 85 T
13 0 0 96 0 G
14 0 0 0 96 T
15 0 0 96 0 G
16 0 0 96 0 G
17 6 5 10 75 T
Type: Heterodimer
Binding TFs: 1io4_C (Runt domain)
1io4_A (bZIP transcription factor, Basic region leucine zipper)
1io4_B (bZIP transcription factor, Basic region leucine zipper)
Binding Sites: 1io4_E
1io4_F
Publications: Tahirov T.H, Inoue-Bungo T, Morii H, Fujikawa A, Sasaki M, Kimura K, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell 104:755-67 (2001). [Pubmed]

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