DNA Binding Motif

Accessions: 6qhd_AB (3D-footprint 20231221)
Names: Signal transducer and activator of transcription 3
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA
Length: 9
Consensus: TTACsGGAA
Weblogo:
PSSM: P0 A C G T
01 8 0 8 80 T
02 0 0 0 96 T
03 96 0 0 0 A
04 0 96 0 0 C
05 10 52 26 8 s
06 0 0 96 0 G
07 0 0 79 17 G
08 96 0 0 0 A
09 71 17 0 8 A
Type: Heterodimer
Binding TFs: 6qhd_A (SH2 domain, STAT protein, all-alpha domain, STAT protein, DNA binding domain)
6qhd_B (SH2 domain, STAT protein, all-alpha domain, STAT protein, DNA binding domain)
Binding Sites: 6qhd_C
6qhd_D
Publications: Belo Y, Mielko Z, Nudelman H, Afek A, Ben-David O, Shahar A, Zarivach R, Gordan R, Arbely E. Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine. Biochim Biophys Acta Gen Subj 1863:1343-1350 (2019). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.