DNA Binding Motif

						

			
Accessions: CENPB_full (HumanTF 1.0), MA0637.1 (JASPAR 2024)

			
Names: CENPB
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 15
Consensus: CCCGywTmswrCGAA
Weblogo: 
PSSM: P0      A      C      G      T
01    685   5580      3    734      C
02    100   5580      4    144      C
03      2   5580      1     14      C
04    173    186   5580    210      G
05     12   5580   1423   2557      y
06   2209    629   1147   1595      w
07    297    433      0   5580      T
08   1706   1638   1157   1079      m
09   1293   1767   1479   1041      s
10   2168    822    760   1830      w
11   3686    694   1893    597      r
12    284   5580     11    100      C
13    872     85   5580      0      G
14   5580    582     61   1903      A
15   5580    286     59    201      A
Type: Heterodimer
Binding TFs: CENPB_full (DDE superfamily endonuclease, Tc5 transposase DNA-binding domain, CENP-B N-terminal DNA-binding domain, Centromere protein B dimerisation domain)
P07199 (DDE superfamily endonuclease, Tc5 transposase DNA-binding domain, CENP-B N-terminal DNA-binding domain, Centromere protein B dimerisation domain)
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Ohzeki J, Nakano M, Okada T, Masumoto H. CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA. J Cell Biol 159:765-75 (2002). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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