DNA Binding Motif

Accessions: 2o6g_EFGH (3D-footprint 20231221)
Names: Interferon regulatory factor 3
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of IRF-3 bound to the interferon-b enhancer
Length: 22
Consensus: GGArAnTGAAAGGGAAAnTnAA
Weblogo:
PSSM: P0 A C G T
01 0 0 96 0 G
02 0 0 96 0 G
03 96 0 0 0 A
04 57 1 38 0 r
05 96 0 0 0 A
06 24 24 24 24 n
07 1 6 5 84 T
08 0 1 92 3 G
09 80 6 5 5 A
10 89 0 7 0 A
11 69 5 1 21 A
12 1 5 84 6 G
13 0 0 96 0 G
14 0 2 94 0 G
15 96 0 0 0 A
16 96 0 0 0 A
17 88 4 3 1 A
18 24 24 24 24 n
19 9 8 7 72 T
20 24 24 24 24 n
21 86 4 3 3 A
22 88 1 3 4 A
Type: Heterodimer
Binding TFs: 2o6g_E / 2o6g_G (Interferon regulatory factor transcription factor)
2o6g_F / 2o6g_H (Interferon regulatory factor transcription factor)
Binding Sites: 2o6g_C
2o6g_D
Publications: Panne D, Maniatis T, Harrison S.C. An atomic model of the interferon-beta enhanceosome. Cell 129:1111-23 (2007). [Pubmed]

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