DNA Binding Motif

Accessions: 2pug_A (3D-footprint 20231221)
Names: PROTEIN (PURINE REPRESSOR)
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES
Length: 8
Consensus: CGcanACg
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 0 0 96 0 G
03 12 60 12 12 c
04 31 21 21 23 a
05 24 24 24 24 n
06 96 0 0 0 A
07 2 88 4 2 C
08 16 19 45 16 g
Binding TFs: 2pug_A (Bacterial regulatory proteins, lacI family, Periplasmic binding proteins and sugar binding domain of LacI family, Periplasmic binding protein-like domain, Periplasmic binding protein domain)
Binding Sites: 2pug_B
Publications: Lu F, Schumacher M.A, Arvidson D.N, Haldimann A, Wanner B.L, Zalkin H, Brennan R.G. Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry 37:971-82 (1998). [Pubmed]

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