DNA Binding Motif

Accessions: 4hn6_AB (3D-footprint 20231221)
Names: Glucocorticoid receptor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex
Length: 14
Consensus: CTcTnCcnnnnGCG
Weblogo:
PSSM: P0 A C G T
01 2 76 2 16 C
02 2 2 2 90 T
03 11 54 15 16 c
04 3 2 2 89 T
05 24 24 24 24 n
06 0 91 3 2 C
07 15 54 16 11 c
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 3 2 89 2 G
13 0 96 0 0 C
14 0 0 96 0 G
Binding TFs: 4hn6_A / 4hn6_B (Zinc finger, C4 type (two domains))
Binding Sites: 4hn6_C
4hn6_D
Publications: Hudson W.H, Youn C, Ortlund E.A. The structural basis of direct glucocorticoid-mediated transrepression. Nature structural & molecular biology 20:53-8 (2013). [Pubmed]

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