DNA Binding Motif
| Accessions: | PurR (DBTBS 1.0) |
| Names: | PurR |
| Organisms: | Bacillus subtilis |
| Libraries: | DBTBS 1.0 1 1 Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic acids research 36:D93-6 (2008). [Pubmed] |
| Length: | 14 |
| Consensus: | AAWwmCGAAyrwTa |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 0.71 0.08 0 0.21 A 02 0.77 0 0.08 0.16 A 03 0.68 0 0 0.32 W 04 0.42 0.07 0 0.51 w 05 0.41 0.51 0.09 0 m 06 0 1 0 0 C 07 0.03 0 0.97 0 G 08 0.96 0 0 0.04 A 09 1 0 0 0 A 10 0.03 0.57 0 0.40 y 11 0.54 0 0.39 0.08 r 12 0.31 0 0.07 0.62 w 13 0.10 0 0 0.90 T 14 0.59 0.17 0 0.25 a |
| Binding TFs: | PurR (Phosphoribosyl transferase domain, Bacterial purine repressor, N-terminal) |
| Binding Sites: | glyA_1 guaC nusB pbuG purA_1 purE_1 purR pyrR_1 xpt_1 ytiP |
| Publications: | Saxild H.H, Brunstedt K, Nielsen K.I, Jarmer H, Nygaard P. Definition of the Bacillus subtilis PurR operator using genetic and bioinformatic tools and expansion of the PurR regulon with glyA, guaC, pbuG, xpt-pbuX, yqhZ-folD, and pbuO. Journal of bacteriology 183:6175-83 (2001). [Pubmed] Saxild H.H, Nygaard P. Regulation of levels of purine biosynthetic enzymes in Bacillus subtilis: effects of changing purine nucleotide pools. Journal of general microbiology 137:2387-94 (1991). [Pubmed] Weng M, Nagy P.L, Zalkin H. Identification of the Bacillus subtilis pur operon repressor. Proceedings of the National Academy of Sciences of the United States of America 92:7455-9 (1995). [Pubmed] Shin B.S, Stein A, Zalkin H. Interaction of Bacillus subtilis purine repressor with DNA. Journal of bacteriology 179:7394-402 (1997). [Pubmed] Rappu P, Shin B.S, Zalkin H, Mäntsälä P. A role for a highly conserved protein of unknown function in regulation of Bacillus subtilis purA by the purine repressor. Journal of bacteriology 181:3810-5 (1999). [Pubmed] Rappu P, Leppihalme M, Mäntsälä P. Mutational analysis of the Bacillus subtilis purA operator site. Current microbiology 51:322-6 (2005). [Pubmed] Ebbole D.J, Zalkin H. Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis. The Journal of biological chemistry 262:8274-87 (1987). [Pubmed] Ebbole D.J, Zalkin H. Bacillus subtilis pur operon expression and regulation. Journal of bacteriology 171:2136-41 (1989). [Pubmed] Ebbole D.J, Zalkin H. Interaction of a putative repressor protein with an extended control region of the Bacillus subtilis pur operon. The Journal of biological chemistry 264:3553-61 (1989). [Pubmed] Weng M, Zalkin H. Mutations in the Bacillus subtilis purine repressor that perturb PRPP effector function in vitro and in vivo. Current microbiology 41:56-9 (2000). [Pubmed] Bera A.K, Zhu J, Zalkin H, Smith J.L. Functional dissection of the Bacillus subtilis pur operator site. Journal of bacteriology 185:4099-109 (2003). [Pubmed] Xuan J, Zalkin H, Weng M. Mutations in PurBox1 of the Bacillus subtilis pur operon control site affect adenine-regulated expression in vivo. Science in China. Series C, Life sciences / Chinese Academy of Sciences 48:133-8 (2005). [Pubmed] Qian J, Cai X, Chu J, Zhuang Y, Zhang S. Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains. Biotechnology letters 28:937-41 (2006). [Pubmed] |
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