DNA Binding Motif

Accessions: 2isz_ABCD (3D-footprint 20231221)
Names: Iron-dependent repressor ideR
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a two-domain IdeR-DNA complex crystal form I
Length: 15
Consensus: AGnanAGGCTnCCCt
Weblogo:
PSSM: P0 A C G T
01 85 5 6 0 A
02 5 11 75 5 G
03 24 24 24 24 n
04 65 10 11 10 a
05 24 24 24 24 n
06 96 0 0 0 A
07 0 0 96 0 G
08 0 0 96 0 G
09 0 96 0 0 C
10 0 0 0 96 T
11 24 24 24 24 n
12 5 80 5 6 C
13 0 96 0 0 C
14 0 86 0 10 C
15 11 10 10 65 t
Binding TFs: 2isz_A / 2isz_B / 2isz_C / 2isz_D (Iron dependent repressor, N-terminal DNA binding domain, Iron dependent repressor, metal binding and dimerisation domain, Winged helix DNA-binding domain)
Binding Sites: 2isz_E
2isz_F
Publications: Wisedchaisri G, Chou C.J, Wu M, Roach C, Rice A.E, Holmes R.K, Beeson C, Hol W.G. Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Biochemistry 46:436-47 (2007). [Pubmed]

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