DNA Binding Motif

						

			
Accessions: 2h8r_AB (3D-footprint 20231221)

			
Names: Hepatocyte nuclear factor 1-beta
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product
Length: 15
Consensus: tGGTGAATtATTAAC
Weblogo: 
PSSM: P0      A      C      G      T
01     16     16     16     48      t
02      8      8     72      8      G
03      0      0     96      0      G
04      0      0      0     96      T
05      0      0     96      0      G
06     96      0      0      0      A
07     96      0      0      0      A
08      0      0      0     96      T
09     16      8     16     56      t
10     96      0      0      0      A
11      0      0      0     96      T
12      0      0      0     96      T
13     96      0      0      0      A
14     96      0      0      0      A
15      0     96      0      0      C
Type: Heterodimer
Binding TFs: 2h8r_A (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
2h8r_B (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
Binding Sites: 2h8r_E
2h8r_F
			
Publications: Lu P, Rha G.B, Chi Y.I. Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta. Biochemistry 46:12071-80 (2007). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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