DNA Binding Motif

Accessions: E2F1_NHLH1 (HumanTF2 1.0)
Names: E2F1_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 26
Consensus: sGCGCswyrmygkkgcmGCAGCTGCk
Weblogo:
PSSM: P0 A C G T
01 63 421 458 0 s
02 0 30 879 3 G
03 7 879 4 0 C
04 7 41 879 5 G
05 2 879 12 124 C
06 88 879 836 77 s
07 360 103 116 300 w
08 129 308 118 325 y
09 267 189 227 195 r
10 338 241 103 197 m
11 100 349 194 236 y
12 187 181 405 105 g
13 188 88 322 281 k
14 138 74 361 306 k
15 186 23 588 82 g
16 170 345 218 147 c
17 255 452 94 78 m
18 110 27 648 94 G
19 9 879 0 7 C
20 879 18 4 54 A
21 31 123 879 22 G
22 8 879 30 10 C
23 71 20 31 879 T
24 13 11 879 9 G
25 100 624 147 8 C
26 21 172 382 303 k
Type: Heterodimer
Binding TFs: E2F1_TF1 (E2F/DP family winged-helix DNA-binding domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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