DNA Binding Motif

						

			
Accessions: HIC2_DBD (HumanTF 1.0), MA0738.1 (JASPAR 2024)

			
Names: HIC2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 9
Consensus: rTGCCMrsy
Weblogo: 
PSSM: P0      A      C      G      T
01   2606    394   2285    367      r
02      0    117      0   4891      T
03    494    354   4891    151      G
04     23   4891     14      0      C
05    435   4891      0     59      C
06   1466   3425      0      0      M
07   2493    710   1290    399      r
08    770   2200   1237    684      s
09    760   1732   1001   1398      y
Type: Heterodimer
Binding TFs: HIC2_DBD (Zinc finger, C2H2 type, Zinc-finger double-stranded RNA-binding, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
Q96JB3 (Zinc finger, C2H2 type, BTB/POZ domain, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
Q96JB3
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Pinte S., Stankovic-Valentin N., Deltour S., Rood B. R., Guerardel C., Leprince D. The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.. J. Biol. Chem. 279:38313-38324 (2004). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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