DNA Binding Motif

Accessions: 5mez_A (3D-footprint 20231221)
Names: MH1 domain of human Smad4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of Smad4-MH1 bound to the GGCT site.
Length: 5
Consensus: GgCTa
Weblogo:
PSSM: P0 A C G T
01 0 0 84 12 G
02 12 12 60 12 g
03 0 96 0 0 C
04 0 0 0 96 T
05 60 12 12 12 a
Binding TFs: 5mez_A (MH1 domain)
Binding Sites: 5mez_D / 5mez_E
Publications: Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragón E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Márquez JA, Massagué J, Macias MJ. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun 8:2070 (2017). [Pubmed]

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