DNA Binding Motif

Accessions: CUX1_TBX21_1 (HumanTF2 1.0)
Names: CUX1_TBX21
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 18
Consensus: kTcACACmyyrATCrATm
Weblogo:
PSSM: P0 A C G T
01 144 126 378 321 k
02 83 190 21 968 T
03 286 968 293 65 c
04 968 35 52 44 A
05 0 968 13 20 C
06 968 14 99 11 A
07 38 968 20 8 C
08 499 469 151 324 m
09 134 285 35 514 y
10 18 292 119 539 y
11 490 26 298 154 r
12 968 5 0 0 A
13 0 9 178 968 T
14 2 968 0 7 C
15 364 4 604 5 r
16 968 0 0 16 A
17 108 0 3 968 T
18 420 330 157 61 m
Type: Heterodimer
Binding TFs: CUX1_TF1 (Homeobox domain, CUT domain, Homeobox KN domain)
TBX21_TF2 (T-box)
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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