DNA Binding Motif

						

			
Accessions: SOX4_DBD (HumanTF 1.0), MA0867.1 (JASPAR 2024)

			
Names: SOX4
Organisms: Homo sapiens, Mus musculus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4; Possible binding to single stranded DNA, HT-SELEX
Length: 16
Consensus: rAACAATTgCAGTGTT
Weblogo: 
PSSM: P0      A      C      G      T
01    138     69    258     81      r
02    547      0      0      0      A
03    547      0      5      0      A
04      0    547      0      0      C
05    547      0      1      0      A
06    547      0      3      1      A
07      0      0      1    547      T
08      0      0     11    547      T
09     54     39    398    149      g
10      0    547      0      0      C
11    547      0      1      0      A
12      0      0    547     25      G
13      0      0      4    547      T
14      1      0    547      0      G
15      0      1      0    547      T
16      2      1      1    547      T
Type: Heterodimer
Binding TFs: Q06945 (HMG (high mobility group) box, Domain of unknown function (DUF1898))
SOX4_DBD (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Q06945
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Harley VR, Clarkson MJ, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Endocr Rev 24:466-87 (2003). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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