DNA Binding Motif

						

			
Accessions: ESR1_DBD (HumanTF 1.0), MA0112.3 (JASPAR 2024)

			
Names: ESR1
Organisms: Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 17
Consensus: arGGTCAcsrTGACCTk
Weblogo: 
PSSM: P0      A      C      G      T
01    232     65    101     88      a
02    402      6    206      0      r
03      0      0    623     34      G
04      2      0    638      0      G
05      0      0      3    549      T
06      1    452      0      2      C
07    471      0     30      0      A
08    108    338     53     23      c
09    127    223    340     65      s
10    235     88    284     13      r
11      0     23      1    510      T
12      2      0    632      0      G
13    491      1      1      0      A
14      0    460      2      0      C
15     15    455      0      0      C
16      0    143      7    502      T
17     35     68    209    204      k
Type: Heterodimer
Binding TFs: P03372 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains), Oestrogen receptor, Oestrogen-type nuclear receptor final C-terminal )
ESR1_DBD (HMG (high mobility group) box, Domain of unknown function (DUF1898))
P03372
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Welboren W.J, van Driel M.A, Janssen-Megens E.M, van Heeringen S.J, Sweep F.C, Span P.N, Stunnenberg H.G. ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands. The EMBO journal 28:1418-28 (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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