DNA Binding Motif

Accessions: 5flv_I (3D-footprint 20231221)
Names: HOMEOBOX PROTEIN NKX-2.5, T-BOX TRANSCRIPTION FACTOR TBX5
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region
Length: 14
Consensus: CACnnTTGAAGnGg
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 79 7 5 5 A
03 11 69 5 11 C
04 24 24 24 24 n
05 24 24 24 24 n
06 5 2 5 84 T
07 0 0 0 96 T
08 0 0 96 0 G
09 79 7 5 5 A
10 96 0 0 0 A
11 0 0 96 0 G
12 24 24 24 24 n
13 0 0 96 0 G
14 11 11 63 11 g
Binding TFs: 5flv_I (Homeobox domain, T-box)
Binding Sites: 5flv_J
5flv_K
Publications: Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG. Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell 164:999-1014 (2016). [Pubmed]

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.