DNA Binding Motif

						

			
Accessions: TP63_DBD (HumanTF 1.0), MA0525.2 (JASPAR 2024)

			
Names: TP63
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 18
Consensus: rACATGTygkrACATGTc
Weblogo: 
PSSM: P0      A      C      G      T
01   1586     26    997    115      r
02   2261      1    185     21      A
03      0   2533      0      0      C
04   2246      0     76      4      A
05    692     33      0   2353      T
06      0      0   4021      0      G
07     14     85      0   3025      T
08     97   1025     26   1961      y
09    649    478   2070     13      g
10    112    681   1656    829      k
11    993      1   2132     47      r
12   2192      0     48     45      A
13      0   2788      0      0      C
14   2151      0      1    192      A
15     75    617      8   2823      T
16      0      0   3532      0      G
17     49    202      1   3126      T
18    701   2099    198    606      c
Type: Heterodimer
Binding TFs: Q9H3D4 (P53 DNA-binding domain, SAM domain (Sterile alpha motif), P53 tetramerisation motif)
TP63_DBD (P53 DNA-binding domain)
Q9H3D4
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Yang A, Zhu Z, Kapranov P, McKeon F, Church G.M, Gingeras T.R, Struhl K. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Molecular cell 24:593-602 (2006). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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