DNA Binding Motif
| Accessions: | RUNX2_DBD_3 (HumanTF 1.0), MA0511.2 (JASPAR 2024) |
| Names: | RUNX2 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, JASPAR 2024 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | Site type: monomeric; SELEX cycle: 4, HT-SELEX |
| Length: | 9 |
| Consensus: | wAACCRCAa |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 3872 1092 326 2748 w 02 6621 556 1215 582 A 03 6621 325 0 0 A 04 0 6621 0 0 C 05 0 6621 0 0 C 06 1914 36 4707 120 R 07 0 6621 0 0 C 08 6621 476 458 191 A 09 4202 677 1134 607 a |
| Type: | Heterodimer |
| Binding TFs: | Q13950 (Runt domain, Runx inhibition domain) RUNX2_DBD (Runt domain) Q13950 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Bowers S. R., Calero-Nieto F. J., Valeaux S., Fernandez-Fuentes N., Cockerill P. N. Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer.. Nucleic Acids Res. 38:6124-6134 (2010). [Pubmed] |
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