DNA Binding Motif

						

			
Accessions: RUNX3_full (HumanTF 1.0), MA0684.1 (JASPAR 2024)

			
Names: RUNX3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 10
Consensus: wAACCrCAaa
Weblogo: 
PSSM: P0      A      C      G      T
01   3952   1515    160   2008      w
02   7636    692   2431    438      A
03   7636    331    273      0      A
04      3   7636      0      0      C
05      0   7636     22      0      C
06   2991     76   4645     41      r
07     30   7636     96     52      C
08   7636    368    202    184      A
09   7636   1015   1772    964      a
10   4131   1198    861   1445      a
Type: Heterodimer
Binding TFs: Q13761 (Runt domain, Runx inhibition domain)
RUNX3_full (Runt domain, Runx inhibition domain)
Q13761
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Bowers S. R., Calero-Nieto F. J., Valeaux S., Fernandez-Fuentes N., Cockerill P. N. Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer.. Nucleic Acids Res. 38:6124-6134 (2010). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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