DNA Binding Motif

Accessions: 6fqq_DE (3D-footprint 20231221)
Names: Homeobox protein TGIF1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA
Length: 12
Consensus: TGACAGCTGKCA
Weblogo:
PSSM: P0 A C G T
01 9 9 6 72 T
02 0 0 96 0 G
03 96 0 0 0 A
04 0 96 0 0 C
05 96 0 0 0 A
06 4 6 72 14 G
07 4 72 11 9 C
08 0 0 0 96 T
09 4 7 81 4 G
10 0 1 28 67 K
11 0 96 0 0 C
12 76 4 9 7 A
Type: Heterodimer
Binding TFs: 6fqq_E (Homeobox domain, Homeobox KN domain)
6fqq_D (Homeobox domain, Homeobox KN domain)
Binding Sites: 6fqq_G / 6fqq_H
Publications: Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ. TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling. Nucleic Acids Res 46:9220-9235 (2018). [Pubmed]

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