DNA Binding Motif

Accessions: E2F2_DBD_3 (HumanTF 1.0), MA0864.1 (JASPAR 2024)
Names: E2F2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4; < 100 counts, HT-SELEX
Length: 16
Consensus: AAAwtGGCGCCAwTTT
Weblogo:
PSSM: P0 A C G T
01 40 0 0 3 A
02 41 0 0 2 A
03 41 0 0 1 A
04 34 1 3 13 w
05 17 1 8 46 t
06 0 6 68 2 G
07 0 0 68 0 G
08 0 31 0 0 C
09 0 0 70 0 G
10 0 31 0 0 C
11 0 31 3 0 C
12 36 3 0 8 A
13 19 1 0 42 w
14 9 0 0 51 T
15 1 0 0 52 T
16 9 3 1 37 T
Type: Heterodimer
Binding TFs: E2F2_DBD (Fork head domain)
Q14209 (E2F/DP family winged-helix DNA-binding domain)
Q14209
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Tao Y., Kassatly R. F., Cress W. D., Horowitz J. M. Subunit composition determines E2F DNA-binding site specificity. Mol. Cell. Biol. 17:6994-7007 (1997). [Pubmed]

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