DNA Binding Motif

Accessions: 5yi2_AB (3D-footprint 20231221)
Names: Zinc transport transcriptional regulator
Organisms: Lactococcus lactis, Lactococcus lactis subsp. lactis (strain IL1403)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of Lactococcus lactis ZitR, wild type in complex with DNA
Length: 13
Consensus: TTaAAnAGTTAAA
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 2 2 2 90 T
03 61 14 13 8 a
04 96 0 0 0 A
05 84 8 2 2 A
06 24 24 24 24 n
07 69 8 14 5 A
08 0 0 96 0 G
09 0 0 0 96 T
10 2 2 5 87 T
11 93 0 0 3 A
12 69 11 14 2 A
13 93 0 1 2 A
Type: Heterodimer
Binding TFs: 5yi2_A (Bacterial regulatory protein, arsR family, MarR family, Iron dependent repressor, N-terminal DNA binding domain, TFIIE alpha subunit, Transcriptional regulator, MarR family, Winged helix-turn-helix DNA-binding, Winged helix DNA-binding domain)
5yi2_B (Bacterial regulatory protein, arsR family, MarR family, Iron dependent repressor, N-terminal DNA binding domain, TFIIE alpha subunit, Transcriptional regulator, MarR family, Winged helix-turn-helix DNA-binding, Winged helix DNA-binding domain)
Binding Sites: 5yi2_C / 5yi2_D
Publications: Zhu R, Song Y, Liu H, Yang Y, Wang S, Yi C, Chen PR. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc Natl Acad Sci U S A 114:13661-13666 (2017). [Pubmed]

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