DNA Binding Motif
| Accessions: | DegU_1 (DBTBS 1.0) |
| Names: | DegU_1 |
| Organisms: | Bacillus subtilis |
| Libraries: | DBTBS 1.0 1 1 Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic acids research 36:D93-6 (2008). [Pubmed] |
| Length: | 5 |
| Consensus: | wAAAw |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 0.61 0 0 0.39 w 02 0.83 0 0 0.17 A 03 0.83 0 0 0.17 A 04 0.83 0 0 0.17 A 05 0.39 0 0 0.61 w |
| Binding TFs: | DegU (Response regulator receiver domain, Bacterial regulatory proteins, luxR family) |
| Binding Sites: | aprE_2 comK_5 sacX_1 sipS_1 sipT wapA_1 wapA_2 |
| Publications: | Ferrari E, Howard S.M, Hoch J.A. Effect of stage 0 sporulation mutations on subtilisin expression. Journal of bacteriology 166:173-9 (1986). [Pubmed] Ogura M, Shimane K, Asai K, Ogasawara N, Tanaka T. Binding of response regulator DegU to the aprE promoter is inhibited by RapG, which is counteracted by extracellular PhrG in Bacillus subtilis. Molecular microbiology 49:1685-97 (2003). [Pubmed] Kunst F, Pascal M, Lepesant-Kejzlarova J, Lepesant J.A, Billault A, Dedonder R. Pleiotropic mutations affecting sporulation conditions and the syntheses of extracellular enzymes in Bacillus subtilis 168. Biochimie 56:1481-9 (1974). [Pubmed] Ayusawa D, Yoneda Y, Yamane K, Maruo B. Pleiotropic phenomena in autolytic enzyme(s) content, flagellation, and simultaneous hyperproduction of extracellular alpha-amylase and protease in a Bacillus subtilis mutant. Journal of bacteriology 124:459-69 (1975). [Pubmed] Yoneda Y, Maruo B. Mutation of Bacillus subtilis causing hyperproduction of alpha-amylase and protease, and its synergistic effect. Journal of bacteriology 124:48-54 (1975). [Pubmed] Tanaka T, Kawata M. Cloning and characterization of Bacillus subtilis iep, which has positive and negative effects on production of extracellular proteases. Journal of bacteriology 170:3593-600 (1988). [Pubmed] Mukai K, Kawata-Mukai M, Tanaka T. Stabilization of phosphorylated Bacillus subtilis DegU by DegR. Journal of bacteriology 174:7954-62 (1992). [Pubmed] Shimane K, Ogura M. Mutational analysis of the helix-turn-helix region of Bacillus subtilis response regulator DegU, and identification of cis-acting sequences for DegU in the aprE and comK promoters. Journal of biochemistry 136:387-97 (2004). [Pubmed] Hahn J, Kong L, Dubnau D. The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subtilis. Journal of bacteriology 176:5753-61 (1994). [Pubmed] van Sinderen D, Venema G. comK acts as an autoregulatory control switch in the signal transduction route to competence in Bacillus subtilis. Journal of bacteriology 176:5762-70 (1994). [Pubmed] Ogura M, Tanaka T. Bacillus subtilis DegU acts as a positive regulator for comK expression. FEBS letters 397:173-6 (1996). [Pubmed] Hamoen L.W, Van Werkhoven A.F, Venema G, Dubnau D. The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America 97:9246-51 (2000). [Pubmed] Crutz A.M, Steinmetz M. Transcription of the Bacillus subtilis sacX and sacY genes, encoding regulators of sucrose metabolism, is both inducible by sucrose and controlled by the DegS-DegU signalling system. Journal of bacteriology 174:6087-95 (1992). [Pubmed] Bolhuis A, Sorokin A, Azevedo V, Ehrlich S.D, Braun P.G, de Jong A, Venema G, Bron S, van Dijl J.M. Bacillus subtilis can modulate its capacity and specificity for protein secretion through temporally controlled expression of the sipS gene for signal peptidase I. Molecular microbiology 22:605-18 (1996). [Pubmed] Tjalsma H, Bolhuis A, van Roosmalen M.L, Wiegert T, Schumann W, Broekhuizen C.P, Quax W.J, Venema G, Bron S, van Dijl J.M. Functional analysis of the secretory precursor processing machinery of Bacillus subtilis: identification of a eubacterial homolog of archaeal and eukaryotic signal peptidases. Genes & development 12:2318-31 (1998). [Pubmed] Dartois V, Débarbouillé M, Kunst F, Rapoport G. Characterization of a novel member of the DegS-DegU regulon affected by salt stress in Bacillus subtilis. Journal of bacteriology 180:1855-61 (1998). [Pubmed] |
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