DNA Binding Motif

Accessions: SOX8_DBD_1 (HumanTF 1.0), MA0868.1 (JASPAR 2024)
Names: SOX8
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4; Possible binding to single stranded DNA, HT-SELEX
Length: 16
Consensus: AACAATrTGCAGTGTT
Weblogo:
PSSM: P0 A C G T
01 460 0 0 7 A
02 460 0 0 0 A
03 1 460 0 0 C
04 460 0 2 0 A
05 460 1 1 1 A
06 0 0 1 460 T
07 162 7 298 37 r
08 1 0 0 460 T
09 30 41 371 89 G
10 0 460 2 2 C
11 460 0 0 0 A
12 1 0 460 2 G
13 0 0 1 460 T
14 0 0 460 0 G
15 1 0 0 460 T
16 0 4 0 460 T
Type: Heterodimer
Binding TFs: SOX8_DBD (HMG (high mobility group) box, Domain of unknown function (DUF1898))
P57073 (HMG (high mobility group) box, Domain of unknown function (DUF1898), Sox developmental protein N terminal )
P57073
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Harley VR, Clarkson MJ, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Endocr Rev 24:466-87 (2003). [Pubmed]

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.