DNA Binding Motif

Accessions: 1zlk_AB (3D-footprint 20231221)
Names: Dormancy Survival Regulator
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR C-terminal Domain-DNA Complex
Length: 15
Consensus: AGGGACTnnAGTCCC
Weblogo:
PSSM: P0 A C G T
01 73 7 7 9 A
02 0 0 96 0 G
03 0 0 96 0 G
04 0 0 96 0 G
05 96 0 0 0 A
06 0 96 0 0 C
07 7 9 7 73 T
08 24 24 24 24 n
09 24 24 24 24 n
10 73 9 7 7 A
11 0 0 96 0 G
12 0 0 0 96 T
13 0 96 0 0 C
14 7 75 7 7 C
15 0 96 0 0 C
Binding TFs: 1zlk_A / 1zlk_B (Bacterial regulatory proteins, luxR family, Sigma-70, region 4)
Binding Sites: 1zlk_C
1zlk_D
Publications: Wisedchaisri G, Wu M, Rice A.E, Roberts D.M, Sherman D.R, Hol W.G. Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. Journal of molecular biology 354:630-41 (2005). [Pubmed]

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