DNA Binding Motif

						

			
Accessions: SP4_full (HumanTF 1.0), MA0685.1 (JASPAR 2024)

			
Names: SP4
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 17
Consensus: ywrGCCACGCCCmCtyy
Weblogo: 
PSSM: P0      A      C      G      T
01    621   1405    823   1622      y
02   2173    156     65   1809      w
03   2600    146   1639    199      r
04    939      6   4774     16      G
05    260   4443      0      4      C
06      2   4492      5    135      C
07   3004    991      3      0      A
08      2   4662      0      0      C
09     10     14   5444     55      G
10      2   4681      4      0      C
11      3   4732      2      0      C
12      0   4667      3     72      C
13   1840   2430      9     67      m
14    113   4276     21   1067      C
15   1140    897    234   3043      t
16    582   1206    363   2078      y
17    967   1180    556   1509      y
Type: Heterodimer
Binding TFs: SP4_full (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q02446 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q02446
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Yokoyama KD, Pollock DD. SP transcription factor paralogs and DNA-binding sites coevolve and adaptively converge in mammals and birds. Genome Biol Evol : (2012;4(11):1102-17.). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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