DNA Binding Motif

						

			
Accessions: 2lkx_A (3D-footprint 20231221)

			
Names: Pituitary homeobox 3
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: NMR structure of the homeodomain of Pitx2 in complex with a TAATCC DNA binding site
Length: 7
Consensus: GgATTAG
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0     96      0      G
02     12     10     64     10      g
03     96      0      0      0      A
04      0      0      0     96      T
05     10     10      0     76      T
06     85      0     11      0      A
07     10     10     74      2      G
Binding TFs: 2lkx_A (Homeobox domain)
Binding Sites: 2lkx_B
2lkx_C
			
Publications: Chaney B.A, Clark-Baldwin K, Dave V, Ma J, Rance M. Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome. Biochemistry 44:7497-511 (2005). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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