DNA Binding Motif

						

			
Accessions: HES5_DBD (HumanTF 1.0), MA0821.1 (JASPAR 2024)

			
Names: HES5
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 12
Consensus: yGrCACGTGCCr
Weblogo: 
PSSM: P0      A      C      G      T
01    216    779     30    535      y
02     47      6   1559      1      G
03    764     63   1559      0      r
04      0   1559      0      0      C
05   1559      0      1      0      A
06      1   1559      0      1      C
07      1      0   1559      0      G
08      0      7      0   1559      T
09      0      0   1559      0      G
10      0   1559     14    267      C
11      0   1559      1     14      C
12    651    153    475    279      r
Type: Heterodimer
Binding TFs: HES5_DBD (Helix-loop-helix DNA-binding domain, Hairy Orange)
Q5TA89 (Helix-loop-helix DNA-binding domain, Hairy Orange)
Q5TA89
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Jones S. An overview of the basic helix-loop-helix proteins. Genome Biol : (2004;5(6):226.). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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