DNA Binding Motif

Accessions: 5cc1_WX (3D-footprint 20231221)
Names: Glucocorticoid receptor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex
Length: 13
Consensus: GnnCAnnntGtnC
Weblogo:
PSSM: P0 A C G T
01 10 0 86 0 G
02 24 24 24 24 n
03 24 24 24 24 n
04 0 96 0 0 C
05 96 0 0 0 A
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 10 12 10 64 t
10 0 0 96 0 G
11 10 10 12 64 t
12 24 24 24 24 n
13 11 85 0 0 C
Type: Heterodimer
Binding TFs: 5cc1_W (Zinc finger, C4 type (two domains))
5cc1_X (Zinc finger, C4 type (two domains))
Binding Sites: 5cc1_Z
5cc1_Y
Publications: Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed]

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