DNA Binding Motif

Accessions: 5zfw_A (3D-footprint 20210203)
Names: Double homeobox protein 4-like protein 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20210203 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of human DUX4 homeodomains bound to A11G DNA mutant
Length: 12
Consensus: CTAATCTnaTCA
Weblogo:
PSSM: P0 A C G T
01 6 84 6 0 C
02 0 0 0 96 T
03 96 0 0 0 A
04 96 0 0 0 A
05 8 12 6 70 T
06 14 70 6 6 C
07 0 0 0 96 T
08 24 24 24 24 n
09 64 12 12 8 a
10 0 6 0 90 T
11 0 96 0 0 C
12 96 0 0 0 A
Binding TFs: 5zfw_A (Homeobox domain, Homeobox KN domain)
Binding Sites: 5zfw_D
5zfw_E
Publications: Li Y, Wu B, Liu H, Gao Y, Yang C, Chen X, Zhang J, Chen Y, Gu Y, Li J, Ma J, Gan J. Structural basis for multiple gene regulation by human DUX4. Biochem Biophys Res Commun 505:1161-1167 (2018). [Pubmed]

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