DNA Binding Motif

Accessions: ISL2_DBD (HumanTF 1.0), MA0914.1 (JASPAR 2024)
Names: ISL2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 8
Consensus: gCAmTTAr
Weblogo:
PSSM: P0 A C G T
01 1585 2616 5631 1102 g
02 160 5631 126 1019 C
03 5631 162 134 248 A
04 3161 5631 171 398 m
05 218 130 169 5631 T
06 278 718 13 5631 T
07 5631 206 59 1354 A
08 5631 1231 3258 1508 r
Type: Heterodimer
Binding TFs: ISL2_DBD (Homeobox domain, Homeobox KN domain)
Q96A47 (Homeobox domain, LIM domain)
Q96A47
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Gong Z., Hew C. L. Zinc and DNA binding properties of a novel LIM homeodomain protein Isl-2.. Biochemistry 33:15149-15158 (1994). [Pubmed]

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