DNA Binding Motif

Accessions: 5i50_B (3D-footprint 2022-04-03)
Names: Myc proto-oncogene protein
Organisms: Homo sapiens
Libraries: 3D-footprint 2022-04-03 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of OmoMYC bound to double-stranded DNA
Length: 5
Consensus: CgTGG
Weblogo:
PSSM: P0 A C G T
01 11 67 9 9 C
02 18 18 42 18 g
03 2 4 2 88 T
04 0 0 96 0 G
05 4 4 84 4 G
Binding TFs: 5i50_B (Helix-loop-helix DNA-binding domain, Myc leucine zipper domain)
Binding Sites: 5i50_C
5i50_D
Publications: Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M. OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene : (2016). [Pubmed]

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