DNA Binding Motif

Accessions: 5e6b_AB (3D-footprint 20231221)
Names: Glucocorticoid receptor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Glucocorticoid receptor DNA binding domain - RELB NF-kB response element complex
Length: 10
Consensus: CGnnnAATnC
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 0 0 88 8 G
03 24 24 24 24 n
04 24 24 24 24 n
05 24 24 24 24 n
06 88 8 0 0 A
07 72 8 8 8 A
08 8 8 8 72 T
09 24 24 24 24 n
10 8 72 8 8 C
Type: Heterodimer
Binding TFs: 5e6b_B (Zinc finger, C4 type (two domains))
5e6b_A (Zinc finger, C4 type (two domains))
Binding Sites: 5e6b_C
5e6b_D
Publications: Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nat Commun 9:1337 (2018). [Pubmed]

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