DNA Binding Motif

						

			
Accessions: MA0523.1 (JASPAR 2024)

			
Names: TCF7L2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: ChIP-seq
Length: 14
Consensus: rrAswTCAAAGgva
Weblogo: 
PSSM: P0      A      C      G      T
01   1525    756   1140    767      r
02   1808    840   1153    387      r
03   3070    136    559    423      A
04     85   1947   2008    148      s
05   2795     26      0   1367      w
06    138      0      0   4050      T
07    155   3304    729      0      C
08   4188      0      0      0      A
09   4103     15     70      0      A
10   4169      0     19      0      A
11    303     37   3848      0      G
12   1035    849   2008    296      g
13   1398   1123   1210    457      v
14   1782    826    757    823      a
Type: Heterodimer
Binding TFs: Q9NQB0 (HMG (high mobility group) box, N-terminal CTNNB1 binding, Domain of unknown function (DUF1898))
Q9NQB0
Binding Sites: MA0523.1.1
MA0523.1.10
MA0523.1.11
MA0523.1.12
MA0523.1.13
MA0523.1.14
MA0523.1.15
MA0523.1.16
MA0523.1.17
MA0523.1.18
MA0523.1.19
MA0523.1.2
MA0523.1.20
MA0523.1.3
MA0523.1.4
MA0523.1.5
MA0523.1.6
MA0523.1.7
MA0523.1.8
MA0523.1.9
			
Publications: Hatzis P, van der Flier L.G, van Driel M.A, Guryev V, Nielsen F, Denissov S, Nijman I.J, Koster J, Santo E.E, Welboren W, Versteeg R, Cuppen E, van de Wetering M, Clevers H, Stunnenberg H.G. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Molecular and cellular biology 28:2732-44 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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