DNA Binding Motif

Accessions: 3tq6_AB (3D-footprint 20231221)
Names: Transcription factor A, mitochondrial
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP
Length: 37
Consensus: ACAGnnAnnnnCCAACAnnnaACAGTCAnnnnCCAAC
Weblogo:
PSSM: P0 A C G T
01 94 0 2 0 A
02 0 96 0 0 C
03 96 0 0 0 A
04 0 0 96 0 G
05 24 24 24 24 n
06 24 24 24 24 n
07 84 5 2 5 A
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 0 96 0 0 C
13 0 96 0 0 C
14 96 0 0 0 A
15 96 0 0 0 A
16 0 93 2 1 C
17 82 5 2 7 A
18 24 24 24 24 n
19 24 24 24 24 n
20 24 24 24 24 n
21 65 10 8 13 a
22 93 2 1 0 A
23 0 96 0 0 C
24 96 0 0 0 A
25 0 0 96 0 G
26 9 5 8 74 T
27 8 78 5 5 C
28 82 5 2 7 A
29 24 24 24 24 n
30 24 24 24 24 n
31 24 24 24 24 n
32 24 24 24 24 n
33 0 93 2 1 C
34 0 96 0 0 C
35 96 0 0 0 A
36 96 0 0 0 A
37 0 94 2 0 C
Type: Heterodimer
Binding TFs: 3tq6_A (HMG (high mobility group) box, Domain of unknown function (DUF1898))
3tq6_B (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: 3tq6_C
3tq6_D
Publications: Rubio-Cosials A, Sidow J.F, Jiménez-Menéndez N, Fernández-Millán P, Montoya J, Jacobs H.T, Coll M, Bernadó P, Solà M. Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter. Nature structural & molecular biology 18:1281-9 (2011). [Pubmed]

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