DNA Binding Motif

Accessions: POU4F3_DBD (HumanTF 1.0), MA0791.1 (JASPAR 2024)
Names: POU4F3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 16
Consensus: aTgmATwATTaATgag
Weblogo:
PSSM: P0 A C G T
01 1663 635 867 761 a
02 292 321 303 4134 T
03 1067 374 4723 1067 g
04 1868 2014 24 69 m
05 3264 42 36 132 A
06 96 21 25 4004 T
07 3041 126 133 1579 w
08 3106 121 126 658 A
09 433 101 166 3805 T
10 479 66 194 3728 T
11 3100 651 789 868 a
12 3447 19 25 22 A
13 212 355 180 3774 T
14 1008 855 4058 1753 g
15 3062 1366 896 981 a
16 1023 836 1729 693 g
Type: Heterodimer
Binding TFs: POU4F3_DBD (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Q15319 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Q15319
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development 135:271-80 (2008). [Pubmed]

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.