DNA Binding Motif

						

			
Accessions: 6wc5_ABI (3D-footprint 2022-04-03)

			
Names: Myocyte-specific enhancer factor 2B
Organisms: Homo sapiens
Libraries: 3D-footprint 2022-04-03 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex
Length: 16
Consensus: CnCTttCTnnnnnnAG
Weblogo: 
PSSM: P0      A      C      G      T
01      0     96      0      0      C
02     24     24     24     24      n
03      0     96      0      0      C
04      0      0      0     96      T
05     23     10     21     42      t
06     21      0     22     53      t
07      0     96      0      0      C
08      0      0      0     96      T
09     24     24     24     24      n
10     24     24     24     24      n
11     24     24     24     24      n
12     24     24     24     24      n
13     24     24     24     24      n
14     24     24     24     24      n
15     96      0      0      0      A
16      0      0     96      0      G
Type: Heterodimer
Binding TFs: 6wc5_B (SRF-type transcription factor (DNA-binding and dimerisation domain))
6wc5_A (SRF-type transcription factor (DNA-binding and dimerisation domain))
6wc5_I (Homeobox domain)
Binding Sites: 6wc5_E
6wc5_F
			
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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