DNA Binding Motif

						

			
Accessions: NKX2-3_full (HumanTF 1.0), MA0672.1 (JASPAR 2024)

			
Names: NKX2-3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 10
Consensus: asCACTTrav
Weblogo: 
PSSM: P0      A      C      G      T
01   3572   2182   1989   1535      a
02   2025   9278   4499    140      s
03     38   9278      0    132      C
04   9278     98     16    250      A
05      8   9278      0      0      C
06      0      0     18   9278      T
07      0    939      0   9278      T
08   4241   1451   5037    343      r
09   9278    917   1831   2437      a
10   3170   2754   2788    566      v
Type: Heterodimer
Binding TFs: NKX2-3_full (Homeobox domain)
Q8TAU0 (Homeobox domain)
Q8TAU0
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Kasahara H., Usheva A., Ueyama T., Aoki H., Horikoshi N., Izumo S. Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein. J. Biol. Chem. 276:4570-4580 (2001). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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