DNA Binding Motif

Accessions: NR3C1_DBD (HumanTF 1.0), MA0113.3 (JASPAR 2024)
Names: NR3C1
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 17
Consensus: rrGwACAywrTGTwCym
Weblogo:
PSSM: P0 A C G T
01 6520 2274 9169 4861 r
02 8885 107 12768 225 r
03 40 7 27337 38 G
04 8932 599 2854 10448 w
05 18207 8 9 10 A
06 0 24481 14 0 C
07 18421 18 698 71 A
08 2470 9569 1583 10711 y
09 7736 3656 5589 5972 w
10 11413 964 7861 1822 r
11 81 565 50 23751 T
12 0 11 27160 5 G
13 8 9 50 24434 T
14 8832 3149 648 10375 w
15 33 24380 5 58 C
16 234 14665 188 9821 y
17 6219 8912 3101 5075 m
Type: Heterodimer
Binding TFs: P04150 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains), Glucocorticoid receptor)
NR3C1_DBD (Zinc finger, C4 type (two domains))
P04150
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Sandelin A, Wasserman W.W. Prediction of nuclear hormone receptor response elements. Molecular endocrinology (Baltimore, Md.) 19:595-606 (2005). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.