DNA Binding Motif

Accessions: SP3_DBD (HumanTF 1.0), MA0746.1 (JASPAR 2024)
Names: SP3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 6, HT-SELEX
Length: 11
Consensus: sCCACrCCCmc
Weblogo:
PSSM: P0 A C G T
01 4161 5583 6609 2223 s
02 1642 6609 394 666 C
03 674 6609 250 346 C
04 4959 1649 185 125 A
05 160 6609 85 227 C
06 3108 463 6609 1720 r
07 142 6609 38 81 C
08 179 6609 53 59 C
09 78 6609 123 1340 C
10 3229 3380 175 665 m
11 1508 6609 1070 2636 c
Type: Heterodimer
Binding TFs: Q02447 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
SP3_DBD (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q02447
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Yokoyama KD, Pollock DD. SP transcription factor paralogs and DNA-binding sites coevolve and adaptively converge in mammals and birds. Genome Biol Evol : (2012;4(11):1102-17.). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.