DNA Binding Motif

Accessions: 5yj3_CD (3D-footprint 20231221)
Names: Telomere zinc finger-associated protein
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of TZAP and telomeric DNA complex
Length: 10
Consensus: tTAGGGtTAG
Weblogo:
PSSM: P0 A C G T
01 12 10 21 53 t
02 0 11 0 85 T
03 96 0 0 0 A
04 0 0 96 0 G
05 0 0 96 0 G
06 0 0 96 0 G
07 10 23 10 53 t
08 0 0 0 96 T
09 96 0 0 0 A
10 0 0 96 0 G
Type: Heterodimer
Binding TFs: 5yj3_C (Zinc finger, C2H2 type, C2H2 type zinc-finger (2 copies), Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
5yj3_D (Zinc finger, C2H2 type, C2H2 type zinc-finger (2 copies), Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Binding Sites: 5yj3_A
5yj3_B
Publications: Zhao Y, Zhang G, He C, Mei Y, Shi Y, Li F. The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA. Cell Res 28:130-134 (2018). [Pubmed]

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