DNA Binding Motif

						

			
Accessions: POU4F2_full (HumanTF 1.0), MA0683.1 (JASPAR 2024)

			
Names: POU4F2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 16
Consensus: aTGmATAATTAATkAg
Weblogo: 
PSSM: P0      A      C      G      T
01   1490    479    771    509      a
02    110    121     53   2757      T
03    193     34   3440     81      G
04   1160   2471      2      5      m
05   3079      6      4     11      A
06      1      0      0   2829      T
07   2990      9     14    258      A
08   2621     82     53    737      A
09     76     54     28   2735      T
10    304      9      8   2669      T
11   3098     26    234     57      A
12   3187      4      9      0      A
13     19     30     69   2761      T
14    130    168   2193   1072      k
15   3078    232    269    236      A
16    739    676   2852    285      g
Type: Heterodimer
Binding TFs: POU4F2_full (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Q12837 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Q12837
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development 135:271-80 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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