DNA Binding Motif

						

			
Accessions: MYBL1_DBD_2 (HumanTF 1.0), MA0776.1 (JASPAR 2024)

			
Names: MYBL1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 12
Consensus: ACCGTTAACsgy
Weblogo: 
PSSM: P0      A      C      G      T
01   1591     25    391    201      A
02    347   2209    122    112      C
03    258   2209    266      0      C
04     49      7   2209      4      G
05      9     26      0   2209      T
06     10      8      0   2209      T
07   2209      0     12     14      A
08   2209     18     24      0      A
09     14   2209      1     12      C
10    164   1733   2209    945      s
11    493    362   2209    888      g
12    332    765     40   1072      y
Type: Heterodimer
Binding TFs: MYBL1_DBD (Myb-like DNA-binding domain, Myb-like DNA-binding domain)
P10243 (Myb-like DNA-binding domain, LMSTEN motif, C-myb, C-terminal, Myb-like DNA-binding domain)
P10243
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Tang H, Goldberg E. A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site. Biol Reprod 86:30 (2012). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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