DNA Binding Motif

Accessions: 2a66_A (3D-footprint 20231221)
Names: Orphan nuclear receptor NR5A2
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Length: 9
Consensus: TGnCCTTGA
Weblogo:
PSSM: P0 A C G T
01 8 11 8 69 T
02 0 0 96 0 G
03 24 24 24 24 n
04 0 96 0 0 C
05 0 96 0 0 C
06 0 8 1 87 T
07 8 11 8 69 T
08 8 8 72 8 G
09 96 0 0 0 A
Binding TFs: 2a66_A (Zinc finger, C4 type (two domains))
Binding Sites: 2a66_B
2a66_C
Publications: Solomon I.H, Hager J.M, Safi R, McDonnell D.P, Redinbo M.R, Ortlund E.A. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of molecular biology 354:1091-102 (2005). [Pubmed]

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