DNA Binding Motif

						

			
Accessions: IRF7_DBD_1 (HumanTF 1.0), MA0772.1 (JASPAR 2024)

			
Names: IRF7
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 14
Consensus: mCGAAAryGAAAvT
Weblogo: 
PSSM: P0      A      C      G      T
01    373    323     71    191      m
02     97    957     50     46      C
03     36     67    957     90      G
04    957      3      1      0      A
05    957      0      0      1      A
06    957      2      1      1      A
07    279    156    505     17      r
08      8    582      2    375      y
09     30      3    957      7      G
10    957     16      4      5      A
11    957      3      3      1      A
12    957     10      7     41      A
13   1184    957   1235    301      v
14    160    153     31    804      T
Type: Heterodimer
Binding TFs: Q92985 (Interferon regulatory factor transcription factor, Interferon-regulatory factor 3)
IRF7_DBD (Interferon regulatory factor transcription factor)
Q92985
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Lin R., Genin P., Mamane Y., Hiscott J. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Mol. Cell. Biol. 20:6342-6353 (2000). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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