DNA Binding Motif

Accessions: FIGLA_DBD (HumanTF 1.0), MA0820.1 (JASPAR 2018)
Names: FIGLA
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2018 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Khan A, Fornes O, Stigliani A, Gheorghe M, Castro-Mondragon JA, van der Lee R, Bessy A, Cheneby , Kulkarni SR, Tan G, Baranasic D, Arenillas DJ, Sandelin A, Vandepoele K, Lenhard B, Ballester B, Wasserman WW, Parcy F, Mathelier A (2017) JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework. Nucleic Acids Res. doi: 10.1093/nar/gkx1126 [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 10
Consensus: wmCACCTGkw
Weblogo:
PSSM: P0 A C G T
01 886 270 175 449 w
02 690 693 160 237 m
03 0 1780 0 29 C
04 1780 46 0 14 A
05 0 1780 527 0 C
06 9 1780 311 0 C
07 56 0 17 1780 T
08 36 33 1780 65 G
09 154 225 569 832 k
10 455 283 289 753 w
Type: Heterodimer
Binding TFs: FIGLA_DBD (Helix-loop-helix DNA-binding domain)
Q6QHK4 (Helix-loop-helix DNA-binding domain)
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Zhao H, Chen ZJ, Qin Y, Shi Y, Wang S, Choi Y, Simpson JL, Rajkovic A. Transcription factor FIGLA is mutated in patients with premature ovarian failure. Am J Hum Genet 82:1342-8 (2008). [Pubmed]

Disclaimer

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